SKETCHY USMLE PHARMACOLOGY 2024 OUTLINE
1. Autonomic Drugs (8)
Chapter 1. Parasympathetic (3)
1.1. Cholinomimetics
1.2. Acetylcholinesterase Inhibitors
1.3. Muscarinic antagonists
Chapter 2. Sympathetic (4)
2.1. Sympathomimetics
2.2. Indirect sympathomimetic
2.3. Alpha drugs
2.4. Beta blockers
Chapter 3. Retired Lessons (1)
3.1. Acetylcholinesterase Inhibitors [Old Version]
2. Cardiovascular & Renal (14)
Chapter 1. Heart Failure Drugs (3)
1.1. Digoxin, milrinone, nesiritide
1.2. ACE inhibitors, ARBs, Aliskiren
1.3. Sacubitril-Valsartan, Milrinone, Nesiritide, Ivabradine
Chapter 2. Diuretics (4)
2.1. Acetazolamide, mannitol
2.2. Loop diuretics
2.3. Thiazides
2.4. Potassium-Sparing Diuretics
Chapter 3. Antihypertensives (2)
3.1. Calcium channel blockers
3.2. Primary hypertension & hypertensive emergency
Chapter 4. Antiarrhythmics (5)
4.1. Class I A-C
4.2. Class II
4.3. Class III
4.4. Class IV
4.5. Class V
3. Blood & Inflammation (12)
Chapter 1. Anticoagulants & Thrombolytics (4)
1.1. Heparin, LMWH, fondaparinux, direct thrombin inhibitors, Xa inhibitors
1.2. Warfarin
1.3. Antiplatelet agents
1.4. Thrombolytics
Chapter 2. Dyslipidemia Drugs (4)
2.1. Statins
2.2. Cholestyramine, ezetimibe
2.3. Fibrates, niacin
2.4. PCSK9 Inhibitors
Chapter 3. Anti-Inflammatory (4)
3.1. NSAIDs
3.2. Gout drugs
3.3. Immunosuppressants
3.4. TNF Inhibitors
4. Smooth Muscle (5)
Chapter 1. Vasoactive
1.1. Nitrates
1.2. Triptans & migraine
1.3. Prostaglandins, prostacyclin, bosentan, PDE5 inhibitors
Chapter 2. Allergy & Pulmonary
2.1. Antihistamines
2.2. Asthma therapy
5. GI & Endocrine (17)
Chapter 1. GI (4)
1.1. Antiemetic agents
1.2. H2 receptor blockers, PPIs
1.3. Laxatives & antidiarrheal agents
1.4. Antidiarrheal Agents
Chapter 2. Diabetes (2)
2.1. Insulin, sulfonylureas, meglitinides, GLP-1 agonists, DPP-4 inhibitors
2.2. Metformin, thiazolidinediones, pramlintide, SGLT2 inhibitors
Chapter 3. Thyroid, Parathyroid & adrenal (4)
3.1. Propylthiouracil, methimazole, levothyroxine
3.2. Bisphosphonates, raloxifene, denosumab, calcitonin
3.3. Teriparatide, vitamin D, cinacalcet, sevelamer
3.4. Glucocorticoids
Chapter 4. Hypothalamic & Pituitary (2)
4.1. Growth hormone, mecasermin, octreotide, pegvisomant
4.2. ADH, DDAVP, ADH receptor antagonists
Chapter 5. Sex Hormones (3)
5.1. SERMs & Aromatase Inhibitors
5.2. LHRH Agonists-GnRH Analogs
5.3. Non-Steroidal Antiandrogens (NSAAs)
Chapter 6. Retired Lessons (2)
6.1. Antiemetic Agents [Old Version]
6.2. Laxatives & Antidiarrheal Agents [Old Version]
6. Neuro & Psych (25)
Chapter 1. Anesthetics & Analgesics (5)
1.1. IV Anesthetics
1.2. Inhaled anesthetics, dantrolene
1.3. Opiates, naloxone, naltrexone
Chapter 2. Antidepressants & Anxiolytics (5)
2.1. SSRIs, SNRIs, cyproheptadine
2.2. Tricyclic antidepressants
2.3. MAO inhibitors
2.4. Bupropion, mirtazapine, trazodone
2.5. Buspirone
Chapter 3. Mood Stabilizers & Antiepileptics Drugs (5)
3.1. Lithium
3.2. Broad-Spectrum Antiepileptics
3.3. Ethosuximide
3.4. Carbamazepine, phenytoin, gabapentin, tiagabine, vigabatrin
3.5. Gabapentin & Pregabalin
Chapter 4. Antipsychotics & Parkinson’s (3)
5.1. First generation antipsychotics
5.2. Second-generation antipsychotics
5.3. Parkinsonism Drugs
Chapter 5. Psychostimulants – Narcolepsy & ADHD (2)
5.1. Narcolepsy Drugs
5.2. Amphetamine, Dexamphetamine, Lisdexamfetamine, Methylphenidate
Chapter 6. Sedative-Hypnotics (3)
6.1. Benzodiazepines & Flumazenil
6.2. Nonbenzodiazepine Hypnotics, Melatonin, Ramelteon
6.3. Barbiturates
Chapter 7. Smoking Cessation Aids (1)
7.1. Varenicline
Chapter 8. Muscle Relaxants (1)
8.1. Skeletal Muscle Relaxants
Chapter 9. Alzheimer’s Medications (1)
9.1. Alzheimer’s Disease Medications
Chapter 10. Retired Lessons (1)
10.1. Valproate, Topiramate, Lamotrigine, Levetiracetam [Old Version]
7. Antimicrobial Drugs (30)
Chapter 1. Cell Wall and Membrane Active Antibiotics
1.1. Penicillin
1.2. Nafcillin, Oxacillin, Methicillin & Dicloxacillin
1.3. Ampicillin, Amoxicillin, Piperacillin, Ticarcillin
1.4. Cephalosporins
1.5. Monobactams & Carbapenems
1.6. Vancomycin
1.7. Daptomycin
Chapter 2. Inhibitors of Bacterial Protein Synthesis
2.1. Tetracyclines
2.2. Macrolides
2.3. Clindamycin
2.4. Chloramphenicol
2.5. Linezolid
2.6. Aminoglycosides
Chapter 3. Antimycobacterials
3.1. Tuberculosis Drugs
3.2. Leprosy drugs
Chapter 4. Other Antibiotics
4.1. Trimethoprim-Sulfamethoxazole
4.2. Fluoroquinolones
4.3. Metronidazole
Chapter 5. Antifungals
5.1. Amphotericin, flucytosine
5.2. Azoles
5.3. Griseofulvin, Terbinafine, Echinocandins
Chapter 6. Antivirals HIV
6.1. NRTIs
6.2. NNRTIs
6.3. Protease inhibitors
6.4. Maraviroc, fusion inhibitors, integrase inhibitors
Chapter 7. Antivirals Hepatitis
7.1. Acyclovir, valacyclovir, famciclovir
7.2. Ganciclovir, valganciclovir, foscarnet, cidofovir
8. Antineoplastics (11)
Chapter 1. Antimetabolites
1.1. Methotrexate, leucovorin, 5-fluorouracil, hydroxyurea
1.2. Azathioprine, 6-mercaptopurine, mycophenolate mofetil
1.3. Cladribine, cytarabine, gemcitabine
Chapter 2. DNA & Cellular Division
2.1. Cyclophosphamide, ifosfamide, busulfan, nitrosoureas (carmustine, lomustine, streptozocin)
2.2. Cisplatin, carboplatin, oxaliplatin, amifostine
2.3. Bleomycin, doxorubicin, daunorubicin, actinomycin D
2.4. Etoposide, teniposide, topotecan, irinotecan
2.5. Vincristine, vinblastine, paclitaxel
Chapter 3. Kinase Inhibitors & Monoclonal Antibodies
3.1. Imatinib, erlotinib, sorafenib, sunitinib, vemurafenib
3.2. Rituximab, cetuximab, bevacizumab, alemtuzumab, trastuzumab
9. Pharmacology Foundations (12)
Chapter 1. Pharmacokinetic Basics (2)
1.1. Membranes – Partition Coefficient, Passive Diffusion, and Active Transport
1.2. Plasma Concentration & Therapeutic Range
Chapter 2. Absorption (2)
2.1. Oral Drug Absorption & Bioavailability (F)
2.2. Intro to Drug Absorption via Parenteral Routes
Chapter 3. Distribution (2)
3.1. Drug Distribution & Protein Binding
3.2. Volume of Distribution
Chapter 4. Metabolism (2)
4.1. Intro to CYP450 Enzymes
4.2. P-Glycoprotein & Enterohepatic Recycling
Chapter 5. Elimination (2)
5.1. Clearance & Area Under the Curve
5.2. Elimination-Rate Constant, Half-Life, Steady State
Chapter 6. Pharmacodynamic Basics (1)
6.1. Agonists, Antagonists, Allosteric Modulators
Chapter 7. Drug-Drug Interactions (1)
7.1. Intro to Pharmacodynamic & Pharmacokinetic Drug Interactions
