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Harvard Update on Severe Asthma 2025

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Harvard Update on Severe Asthma 2025

Gain cutting-edge insights into the assessment and management of severe asthma through this two-day, live, hybrid (in-person and online) course led by the multidisciplinary team from the Severe Asthma Program at Brigham and Women’s Hospital and the Mass General Brigham Asthma Center. The course will explore both pediatric and adult asthma, focusing on comprehensive evaluation, diagnosis, and modern treatment approaches. Day one will focus on the assessment of severe asthma and related comorbidities, while day two will cover treatment strategies, including novel and emerging therapies. Topics include immunology and genetics of severe asthma, aspirin-exacerbated respiratory disease, eosinophilic lung diseases (including allergic bronchopulmonary aspergillosis), occupational asthma, obesity-related asthma, and pediatric considerations. Additional sessions will discuss gastroesophageal reflux disease, upper airway obstruction, and sinusitis/nasal polyposis — featuring insights from gastroenterology, otolaryngology, and voice specialists. Participants will receive an in-depth review of current GINA and NAEPP Guidelines, the latest biologic therapies, and innovative treatment approaches. Interactive lectures, multidisciplinary case discussions, and live Q&A sessions will ensure participants leave with practical skills to manage complex asthma cases effectively.

* Date of Original Release: March 8–9, 2025

LEARNING OBJECTIVES

Upon completion of this activity, participants will be able to:

  • Systematically evaluate patients with difficult-to-control or severe asthma using structured clinical and diagnostic protocols.
  • Identify and differentiate specific severe asthma phenotypes and endotypes to enable precision-based treatment.
  • Apply current GINA and NAEPP guideline updates and utilize novel biologic therapies in the management of severe asthma.
  • Recognize and manage comorbid conditions such as gastroesophageal reflux disease, sinusitis/nasal polyposis, and obesity-related asthma.
  • Integrate multidisciplinary insights from pulmonology, allergy, otolaryngology, and gastroenterology into individualized asthma care plans.
  • Engage in case-based discussions and expert-led sessions to enhance decision-making in severe asthma management.

WHO SHOULD ATTEND

  • Pulmonologists and allergists specializing in asthma care.
  • Primary care physicians managing asthma patients.
  • Nurse practitioners and physician assistants working in respiratory medicine.
  • Medical trainees seeking advanced education in asthma treatment and management.
  • Researchers focused on asthma pathophysiology and emerging therapeutics.

HARVARD SEVERE ASTHMA UPDATE 2025

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HARVARD UPDATE ON SEVERE ASTHMA 2025 TOPICS

1. Live Lectures

1. Welcome and Introduction to Online Audience – Elliot Israel, MD; Nora Barrett, MD

2. Asthma Genetics and the Environment in Severe Asthma – Benjamin Raby, MD, MPH

3. Diagnostic Assessment of Severe Asthma – Nora Barrett, MD

4. Drivers of Asthma in School-Aged Children – Wanda Phipatanakul, MD

5. Indoor Environments and Asthma Exacerbations – Adam Haber, PhD

6. Pathophysiologic Insights into Severe Asthma from Novel Imaging Techniques – Carrie Pistenmaa, MD

7. Diagnostic Considerations in Children with Severe Asthma – Benjamin Nelson, MD

8. Insights from the Severe Asthma Research Program (SARP) – Bruce Levy, MD

9. Guest Lecture – Molecular Sub-Phenotypes in Asthma – Prescott Woodruff, MD, MPH

10. Interactive Case Discussions – Justin Salciccioli, MBBS; Nora Barrett, MD; Elliot Israel, MD

2. Pre-Recorded Lectures

1. Asthma Mimics – Consider Tracheobronchomalacia – Adel El-Boueiz, MD, MS; Majid Shafiq, MD, MPH

2. The Microbiome and Asthma – Peggy Lai, MD, MPH

3. New Recommendations for the Interpretation of PFTs – Nancy Lange-Vaidya, MD, MPH

4. Airway Oscillometry in Adults and Very Young Children – Adel El-Boueiz, MD; Peter Moschovis, MD, MPH

5. Obesity, Diabetes, and Asthma – Dinah Foer, MD

1. Live Lectures

1. Managing Asthma with Aspirin-Exacerbated Respiratory Disease – Tanya Laidlaw, MD

2. Choosing Among the Biologics for Severe Asthma – Elliot Israel, MD

3. Clinical Remission in Asthma – A Goal of Guidelines Therapy? – Justin Salciccioli, MBBS

4. Eosinophilic Lung Disease and Asthma – Joshua Boyce, MD

5. Guest Lecture – Managing Severe Asthma in Children – Daniel Jackson, MD

6. Cigarette Smoking, COPD, and Chronic Obstructive Asthma – Carrie Pistenmaa, MD

7. “Anti-Inflammatory Rescue” – Options and Challenges – Nancy Lange-Vaidya, MD, MPH

8. Novel Therapies – A Look into the Future – Elliot Israel, MD

9. Case Discussions – Jonathan Gaffin, MD, MMSc; Elliot Israel, MD

2. Pre-Recorded Lectures

1. Gastroesophageal Reflux and Severe Asthma – Christopher Velez, MD

2. Laryngeal Disordered Breathing Mimicking Severe Asthma – Thomas Carroll, MD & Lindey Gordon, MS, CCC-SLP

3. Treating Rhinosinusitis and Nasal Polyposis – Alice Maxfield, MD

4. Occupational Exposures and Severe Asthma – Robert McCunney, MD

5. What Distinguishes Asthmatic from Non-Asthmatic Allergic Responses in the Airways? – Benjamin Medoff, MD

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