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SKETCHY USMLE Step 1/Pre-Clinical 2025

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SKETCHY USMLE Step 1/Pre-Clinical is a comprehensive visual learning platform designed to help medical students master the core scientific concepts required for the USMLE Step 1 exam. Through engaging animations, visual mnemonics, and concise explanations, Sketchy breaks down complex pre-clinical topics into digestible, memorable content. This visual-first approach helps students understand deeply and retain high-yield information crucial for exam success.

* Checked and Updated: January 15, 2025

Who Should Use SKETCHY USMLE Step 1/Preclinical?

  • Medical students preparing for the USMLE Step 1 exam
  • Learners looking for an efficient, memory-friendly approach to tackle large volumes of pre-clinical content
  • Students who benefit from storytelling, visuals, and animation to enhance understanding and recall
  • Anyone seeking a high-yield review tool that focuses on the most frequently tested Step 1 topics

SKETCHY USMLE® STEP 1/PRECLINICAL REVIEW 2025

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SKETCHY USMLE STEP 1/PRECLINICAL 2025 OUTLINE

1. Gram Positive Cocci (7) – Sample

2. Gram Positive Bacilli (7) – Sample

3. Gram-Positive Branching Filamentous Rods (2) – Sample

4. Gram-Negative Cocci (3)

5. Gram-Negative Bacilli – Enteric tract (10)

6. Gram-Negative Bacilli – Respiratory tract (5)

7. Gram-Negative Bacilli – Zoonotics (5)

8. Mycobacteria (3)

9. Spirochetes (4)

10. Gram-Indeterminate Bacteria (7)

1. Systemic Mycoses (4) – Sample

2. Cutaneous Mycoses (3)

3. Opportunistic Fungal Infections (5)

1. RNA Viruses – Positive Sense (13) – Sample

2. RNA Viruses – Negative Sense (8)

3. DNA Viruses (13)

1. Protozoa of the Intestinal Tract (3) – Sample

2. Protozoa of the CNS (3)

3. Protozoa of the Blood (5)

4. Protozoa – Other Tissue (1)

5. Helminths – Nematodes (2)

6. Helminths – Trematodes and Cestodes (2)

7. Ectoparasites (1)

1. Parasympathetic (3) – Sample

2. Sympathetic (4)

1. Heart Failure Drugs (3) – Sample

2. Diuretics (4)

3. Antihypertensives (2)

4. Antiarrhythmics (5)

1. Anticoagulants & Thrombolytics (4)Sample

2. Dyslipidemia Drugs (4)

3. Anti-Inflammatory (4)

1. Vasoactive (3)Sample

2. Allergy & Pulmonary (2)

1. GI (4)Sample

2. Diabetes (2)

3. Thyroid, Parathyroid & Adrenal (4)

4. Hypothalamic & Pituitary (2)

5. Sex Hormones (3)

1. Sedative-hypnotics (3)Sample

2. Anesthetics & Analgesics (5)

3. Mood Stabilizers & Antiepileptic Drugs (5)

4. Antipsychotics & Parkinson’s (3)

5. Psychostimulants: Narcolepsy & ADHD (2)

6. Sedative-Hypnotics (3)

7. Smoking Cessation Aids (1)

8. Alzheimer’s Medications (1)

9. Muscle Relaxants (1)

1. Cell Wall and Membrane Active Antibiotics (8)Sample

2. Inhibitors of Bacterial Protein Synthesis (7)

3. Antimycobacterials (2)

4. Other Antibiotics (3)

5. Antifungals (3)

6. Antivirals HIV (4)

7. Antivirals other (2)

1. Antimetabolites (3) – Sample

2. DNA & Cellular Division (5)

3. Kinase Inhibitors & Monoclonal Antibodies (2)

4. Immunology (1)

1. Pharmacokinetic Basics (2) – Sample

2. Absorption (1)

3. Distribution (2)

4. Metabolism (2)

5. Elimination (2)

6. Pharmacodynamic Basics (1)

7. Drug-Drug Interactions (1)

Chapter 1 – Ischemic Heart Disease (3)Sample

Chapter 2 – Heart Failure (2)

Chapter 3 – Myocardial & Pericardial Disorders (4)

Chapter 4 – Valvular Disorders (3)

Chapter 5 – Congenital Heart Disease (2)

Chapter 1 – Atherosclerosis (2) – Sample

Chapter 2 – Hypertension (3)

Chapter 3 – Vasculitides (2)

Chapter 1 – Obstructive Lung Disease (2)Sample

Chapter 2 – Restrictive Lung Disease (4)

Chapter 3 – Acute Lung Disease (3)

Chapter 4 – Lung Cancer (1)

Chapter 1 – Acute Kidney Injury (3)Sample

Chapter 2 – Glomerulopathy (2)

Chapter 3 – Congenital & Chronic Kidney Disease (2)

Chapter 4 – Urinary Tract Obstruction (3)

Chapter 5 – Renal Cancer (1)

Chapter 6 – Volume, Electrolyte & Acid/Base Disorders (5)

Chapter 1 – Esophageal & Gastric Disorders (4)Sample

Chapter 2 – Small Bowel Disorders (4)

Chapter 3 – Colorectal & Anal Disorders (4)

Chapter 1 – Gallbladder & Biliary Tract Disease (3) – Sample

Chapter 2 – Liver Disease (4)

Chapter 3 – Pancreatic Disease (2)

Chapter 1 – Hypothalamic & Pituitary Disorders (4) – Sample

Chapter 2 – Adrenal Disorders (5) – Sample

Chapter 3 – Diabetes (3)

Chapter 4 – Thyroid & Parathyroid (6)

Chapter 1 – Uterine & Vulvovaginal Disorders (3)Sample

Chapter 2 – Reproductive Hormones & Ovarian Disorders (4)

Chapter 3 – Gestational Disorders (3)

Chapter 4 – Breast (2)

Chapter 5 – Male GU (3)

Chapter 1 – Microcytic Anemias (2) – Sample

Chapter 2 – Normocytic & Macrocytic Anemias (5)

Chapter 3 – Coagulopathies & Platelet (5)

Chapter 1 – Myeloid Disorders (3) – Sample

Chapter 2 – Lymphoid & Plasma Cell Disorders (4)

Chapter 1 – Autoimmune & Amyloidosis (4)Sample

Chapter 2 – Immunodeficiency (4)

Chapter 1 – Bone (5)Sample

Chapter 2 – Joint (3)

Chapter 3 – Muscle (2)

Chapter 4 – Derm (2)

Chapter 1 – Cerebrovascular (2) – Sample

Chapter 2 – Intracranial Hypertension and Tumors (4)

Chapter 3 – Spinal Cord & Peripheral Nerve (3)

Chapter 4 – Congenital & Neurocutaneous (2)

Chapter 5 – Neurodegenerative (2)

Chapter 1 Carbohydrates (17)

Chapter 2 Amino Acids And Proteins (10)

Chapter 3 Lipids (4)

Chapter 4 Alcohol Metabolism (1)

Chapter 1 Parts of Cell (1)

Chapter 1 Lysosomal Storage Diseases (4)

Chapter 1 Water Soluble Vitamins (9)

Chapter 2 Fat Soluble Vitamins (4)

Chapter 1 Population Genetics (1)

Chapter 2 X-linked Dominant Diseases (1)

Chapter 3 Trinucleotide Repeat Diseases (1)

1. Diffusion Potential, Resting Membrane Potential, and Action Potentials (2)

2. Neuromuscular & Synaptic Transmission (1)

3. Bone (2)

4. Skeletal Muscle (3)

1. Organization and Features of ANS (4)

2. Autonomic Receptors (2)

1. Hemodynamics (3)

2. Cardiac Electrophysiology (3)

3. Cardiac Muscle & Cardiac Output (4)

4. Cardiac Cycle (1)

5. Regulation of Arterial Pressure (2)

6. Integrative Functions of the Cardiovascular System (2)

1. Thyroid Hormones (2)

2. Endocrine Pancreas (1)

3. Calcium & Phosphate Metabolism (2)

4. Hypothalamic-Pituitary Axis (3)

1. Male Reproduction (1)

2. Female Reproduction (2)

1. Acid-Base Disorders (5)

2. Water Balance – Concentration & Dilution of Urine (5)

3. Body Fluids (1)

1. Lung Volumes & Capacities (2)

2. Mechanics of Breathing (5)

3. Oxygen Transport (4)

4. Carbon Dioxide Transport (1)

5. Pulmonary Circulation (2)

6. Control of Breathing (2)

7. Integrative Functions of the Respiratory System (2)

1. Structure of the GI Tract (1)

2. Regulation of the GI Tract (2)

3. Gastrointestinal Secretions (2)

1. Blood-Brain Barrier & Cerebrospinal Fluid (1)

2. Organization of Nervous System (2)

3. Sensory Systems (4)

1. Blood Components & Function (1)

1. Cranial Nerves (14)

2. Skull and Face (5)

3. Vasculature (1)

4. Pharynx & Ear (2)

5. Neck (1)

6. Larynx (2)

1. Chest Wall (1)

2. Heart (3)

3. Vasculature (2)

4. Lungs (3)

1. Spine (1)

1. Abdominal Overview (1)

2. Abdominal Wall (2)

3. Vasculature (5)

1. Vasculature (1)

1. Brachial Plexus (2)

1. Knee (1)

2. Innervation of Lower Extremity (4)

3. Ankle & Foot (1)

Chapter 1 Biostatistics & Data (11)

Chapter 1 Study Designs (7)

Chapter 2 Clinical Research (2)

Chapter 3 Validity (2)

1. Cells of the Immune System (1)

2. Branches of the Immune System (1)

3. Organs of the Immune System (1)

1. Complement (2)

2. Recognizing Invaders (1)

3. Phagocytes (2)

4. Response to Viruses (1)

1. Antibodies & Receptors (2)

2. Cell-Mediated Immunity (T-Cells) (6)

3. Humoral Immunity (B-Cells) (3)

1. Hypersensitivity Reactions (3)

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