KAPLAN USMLE® Step 1 Prep 2018

1

Gonad Development

2

Week 1 Beginning of Development

3

Week 2 Formation of the Bilaminar Embryo

4

Embryonic Period (Weeks 3-8)

5

Histology Epithelia

6

Cytoskeletal and Cell Surface Elements

1

Vertebral Column

2

Spinal Nerves

3

Autonomic Nervous System

4

Sympathetic Nervous System

5

Parasympathetic Nervous System

1

Head and Neck

2

Embryology of the Head and Neck

1

Lower Limb Lumbosacral Plexus

2

Blood Supply of the Lower Limb

3

The Knee and Ankle

1

Chest Wall

2

Lungs

3

Heart

4

Development of Heart

5

Development of Atrial Septums

6

Atrial Septal Defect

7

Ventricular Septum

8

Fetal Heart Abnormalities

9

Fetal Circulation and Shunts

10

Adult Heart

11

Cardiac Conduction

12

Mediastinum

1

Abdominal Wall

2

Inguinal Hernia

3

Descent of Testis and Femoral Hernia

4

Embryology of Gut Tube

5

Foregut development

6

Pancreas and Duodenum Development

7

Development of the Spleen

8

Peritoneum and Rotation of the Gut

9

Histology of the GI Tract

10

Intestinal Histology

11

Histology of Salivary Glands, Pancreas, and Liver

12

Arterial Blood Supply of the GI Tract

13

Venous Drainage of the GI Tract

14

Urinary System

15

Embryology of Urinary System

16

Pelvis and Perineum

17

Abdominal Imaging

18

Upper Limb Brachial Plexus

19

Nerve Injuries

20

Arterial Supply and Rotator Cuff

1

Basal Ganglia

2

Basal Ganglia Pathways

3

Basal Ganglia Structures

4

Diseases of the Basal Ganglia

1

Cerebral Cortex Right Hemisphere

2

Blood Supply of the Brain

3

Cerebrovascular Disorders

4

Cerebral Cortex Left Hemisphere

5

Clinical Correlates Part 1

6

Clinical Correlates Part 2

7

CNS Blood Supply and Stroke Related Deficits

8

Key Features of Lobes

1

Diencephalon

2

Thalamus

3

Hypothalamus

4

Epithalamus

1

Histology of the Nervous System

2

Axonal transport

3

Glial and Supporting Cells

4

Conditions of Impaired Myelination

5

Histology of the Peripheral Nervous System

6

Blood Brain Barrier

7

Axotomy, Chromatolysis, and Regeneration

8

Primary Tumors

1

Limbic System

1

Nervous System Organization and Development

2

Congenital Malformations of the Nervous System

3

Germ Layer Derivatives Ectoderm

4

Autonomic Nervous System General Organization

5

Parasympathetic and Sympathetic Outflow

6

Cross Section of Spinal Cord

1

The Brain Stem

2

Upper Midbrain

3

Lower Midbrain

4

Middle Pons

5

Lower Pons

6

Medulla

7

Cranial Nerves I And II

8

Cranial Nerves III, IV, And VI

9

Cranial Nerve V, VII and VIII

10

Cranial Nerves IX, X, XI and XII

11

Trigeminal nuclei

12

Corticobulbar (Corticonuclear) Innervation of Cranial Nerve Nuclei

13

Components Of The Ear, Auditory, And Vestibular System

14

Auditory System

15

Vestibular System

16

Caloric Test

17

Horizontal Conjugate Gaze

18

Blood Supply To The Brain Stem

19

Medullary Lesions

20

Pons Lesions

21

Midbrain Lesions

22

Strategy for the Study of Lesions

1

The Cerebellum

2

Cerebellar Cytoarchitecture

3

Circuitry

4

Cerebellar Lesions

1

The Spinal Cord General Features

2

Dorsal Horn

3

Ventral Horn

4

Neural Systems Introduction

5

Motor System

6

Commonly Tested Muscle Stretch Reflexes

7

UMN vs LMN Lesions

8

Sensory Systems

9

Spinocerebellar Pathways

10

Spinal Cord Levels and Pathways

11

Brown-Se´quard Syndrome

12

Lesions of the Spinal Cord I

13

Lesions of the Spinal Cord II

1

Ventricular System

1

Visual Pathways

2

Visual Reflexes

3

Clinical Correlates Pupillary Abnormalities

4

Eyeball And Optic Nerve

5

Visual Field Defects

1

Alzheimer Disease

2

Cystic Fibrosis (CF)

3

Congestive Heart Failure (CHF)

4

Multiple Sclerosis (MS)

5

Osteoporosis

6

Pernicious Anemia

7

Acute Pancreatitis

8

Visual Pathways

9

Spermatogenesis

1

Physiology of Substance Abuse

2

Alcohol and Alcoholism

3

Common Abused Substances

4

Other Abused Substances

5

Substance-Abusing Physicians

1

Sexual Behavior in the United States

2

Paraphilias

3

Sexual Dysfunctions

4

Masturbation

5

Homosexuality

6

Sexuality and Aging

1

Learning and Behavior

2

Behavior Therapy and Behavior Modification

1

General Issues

2

Four Clusters of Defenses

3

Transference

1

Psychologic Health and Physical Health

2

Psychologic Adjustment and Physical Health

3

Intelligence Q

4

Personality Tests

5

Neuropsychologic Test

1

Developmental Milestones

2

Applying Child-Development Principles

3

Abuse

1

Sleep Architecture

2

Developmental Aspects of Sleep

3

Sleep Disorders

4

Biochemistry of Sleep

1

General Rules about Physician-Patient Relationships

1

Childhood Disorders

2

Schizophrenia

3

Mood Disorderss

4

Eating and Anxiety Disorders

5

Obsessive Compulsive and Related Disorders

6

Personality Disorders

1

Tourette Syndrome

2

HIV-Related Dementia

3

Delirium versus Dementia

4

Hemispheric Dominance

5

Brain and Behavior

1

Antipsychotics (Neuroleptics)

2

Antidepressants

3

Mood Stabilizers

4

Anxiolytics (Antianxiety)

1

Legal Issues Related to Medical Practice

1

Epidemiologic Measures

2

Screening Tests

3

Research Study

1

Key Probability Rules

2

Descriptive Statistics Summarizing the Data

3

Inferential Statistics

4

Nominal, Ordinal, Interval, and Ratio Scales

5

Statistical Tests

1

Overview The Central Dogma of Molecular Biology

2

Nucleotide Structure and Nomenclature

3

Nucleic Acids

4

Organization of DNA

1

Overview of DNA Replication

2

Comparison of DNA and RNA Synthesis

3

Steps of DNA Replication

4

DNA Repair

1

Overview of Transcription

2

RNA Polymerases

3

Transcription Important Concepts and Terminology

4

Production of Prokaryotic Messenger RNA

5

Production of Eukaryotic Messenger RNA

6

Alternative Splicing-Eukaryotic Primary Pre-mRNA Transcripts

7

Ribosomal RNA (rRNA) Is Used to Construct Ribosomes

8

Transfer RNA Carries Activated Amino Acids for Translation

1

Overview of Translation

2

Mutations

3

Amino Acid Activation and Codon Translation by tRNAs

4

Translation (Protein Synthesis)

5

Inhibitors of Protein Synthesis

6

Protein Folding and Subunit Assembly

7

Translation Occurs on Free Ribosomes and on the RER

8

Co- and Posttranslational Covalent Modifications

9

Posttranslational Modifications of Collagen

1

Overview of Genetic Regulation

2

Regulation of Eukaryotic Gene Expression

1

Overview of Recombinant DNA Technology

2

Human Genome Project and Cloning Genes

3

Medical Application of Recombinant DNA

4

RNA Interference

1

Blotting Techniques

2

Polymerase Chain Reaction (PCR)

1

Amino Acids

2

Protein Turnover

3

Biochemical Reactions

1

Hormones and Signal Transduction

2

Water-Soluble Hormones Mechanism

3

G-Proteins in Signal Transduction

4

Lipid Soluble Hormones

1

Water Soluble Vitamins

2

Lipid Soluble Vitamins

1

Metabolic Sources of Energy and Energy Storage

2

Patterns of Fuel Metabolism in Tissues

1

Carbohydrate Digestion

2

Glucose Transport

3

Glycolysis

4

Galactose Metabolism

5

Fructose Metabolism

6

Pyruvate Dehydrogenase

1

Citric Acid Cycle

2

Electron Transport Chain and Oxidative Phosphorylation

1

Glycogen Synthesis and Glycogenolysis

2

Genetic Deficiencies of Enzymes in Glycogen Metabolism

3

Gluconeogenesis

4

Hexose Monophosphate Shunt

5

Chapter 14 Questions

1

Fatty Acid Nomenclature

2

Lipid Digestion

3

Fatty Acid Biosynthesis

4

Triglyceride (Triacylglycerol) Synthesis

5

Lipoprotein Metabolism

6

Hyperlipidemias

7

Cholesterol Metabolism

1

Lipid Mobilization

2

Fatty Acid Oxidation

3

Ketone Body Metabolism

4

Sphingolipids

5

Chapter 16 Questions

1

Overview (Amino Acid Metabolism)s

2

Removal and Excretion of Amino Groups

3

Urea Cycle

4

5

6

7

8

1

Overview (Purine and Pyrimidine Metabolism)

2

Pyrimidine Synthesis

3

Purine Synthesis

4

Purine Catabolism and the Salvage Enzyme HGPRT

5

Chapter 17 and 18 Questions

1

Abetalipoproteinemia

2

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

3

Li-Fraumeni

4

Sickle Cell Disease

5

Fatty Acid Oxidation

1

Basic Definitions

2

Major Modes of Inheritance

3

Important Principles Characterizing Single-Gene Diseases

1

Definition (Population Genetics)

2

Hardy-Weinberg Equilibrium

3

Factors Responsible for Genetic Variation among Populations

1

Overview (Cytogenics)

2

Basic Definitions and Terminology

3

Numerical Chromosome Abnormalities

4

Structural Chromosome Abnormalities

5

Other Chromosome Abnormalities

6

Advances in Molecular Cytogenics

1

Multifactorial Inheritance

1

Overview (Gene Mapping)

2

Gene Mapping Linkage Analysis

1

Overview (Genetic Diagnosis)

2

Genetic Diagnosis

3

Applications of Genetic Diagnosis